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TGFB3 Involved in embryogenesis and cell differentiation. Homodimer; disulfide-linked. Interacts with ASPN. Belongs to the TGF-beta family. Note: This description may include information from UniProtKB.
Protein type: Cell development/differentiation; Ligand, receptor tyrosine kinase; Motility/polarity/chemotaxis; Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 14q24.3
Cellular Component: extracellular matrix; extracellular region; extracellular space; intracellular membrane-bound organelle; plasma membrane
Molecular Function: cytokine activity; identical protein binding; protein binding; punt binding; transforming growth factor beta binding
Biological Process: alveolus development; BMP signaling pathway; cell development; in utero embryonic development; intercellular junction assembly and maintenance; mammary gland development; negative regulation of cell proliferation; negative regulation of DNA replication; negative regulation of neuron apoptosis; palate development; platelet degranulation; positive regulation of apoptosis; positive regulation of bone mineralization; positive regulation of collagen biosynthetic process; positive regulation of DNA replication; positive regulation of filopodium formation; positive regulation of protein secretion; positive regulation of stress fiber formation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; regulation of apoptosis; regulation of MAPKKK cascade; response to hypoxia; response to progesterone stimulus; salivary gland morphogenesis; transforming growth factor beta receptor signaling pathway; uterine wall breakdown
Disease: Arrhythmogenic Right Ventricular Dysplasia, Familial, 1; Rienhoff Syndrome
Reference #:  P10600 (UniProtKB)
Alt. Names/Synonyms: ARVD; FLJ16571; TGF-beta-3; TGF-beta3; TGFB3; Transforming growth factor beta-3; transforming growth factor, beta 3
Gene Symbols: TGFB3
Molecular weight: 47,328 Da
Basal Isoelectric point: 8.31  Predict pI for various phosphorylation states
CST Pathways:  Regulation of P38 MAPKs  |  Wnt/ß-Catenin Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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