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DDR2 This tyrosine kinase receptor for fibrillar collagen mediates fibroblast migration and proliferation. Contributes to cutaneous wound healing. Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily. Note: This description may include information from UniProtKB.
Protein type: DDR family; EC; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor); TK group
Chromosomal Location of Human Ortholog: 1q23.3
Cellular Component: actin cytoskeleton; focal adhesion; plasma membrane
Molecular Function: collagen binding; protein binding; transmembrane receptor protein tyrosine kinase activity
Biological Process: biomineral formation; cell adhesion; collagen fibril organization; extracellular matrix organization and biogenesis; peptidyl-tyrosine phosphorylation; positive regulation of fibroblast proliferation; positive regulation of osteoblast differentiation; positive regulation of protein kinase activity; positive regulation of transcription factor activity; protein amino acid autophosphorylation; regulation of bone mineralization; signal transduction
Disease: Spondylometaepiphyseal Dysplasia, Short Limb-hand Type
Reference #:  Q16832 (UniProtKB)
Alt. Names/Synonyms: CD167 antigen-like family member B; cell migration-inducing protein 20; DDR2; Discoidin domain receptor 2; discoidin domain receptor family, member 2; discoidin domain receptor tyrosine kinase 2; Discoidin domain-containing receptor 2; MIG20a; migration-inducing gene 16 protein; neurotrophic tyrosine kinase receptor related 3; Neurotrophic tyrosine kinase, receptor-related 3; NTRKR3; Receptor protein-tyrosine kinase TKT; TKT; TYRO10; Tyrosine-protein kinase TYRO10
Gene Symbols: DDR2
Molecular weight: 96,736 Da
Basal Isoelectric point: 5.2  Predict pI for various phosphorylation states
CST Pathways:  Tyrosine Kinases & Substrates
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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