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ANGPT2 Binds to TEK/TIE2, competing for the ANGPT1 binding site, and modulating ANGPT1 signaling. Can induce tyrosine phosphorylation of TEK/TIE2 in the absence of ANGPT1. In the absence of angiogenic inducers, such as VEGF, ANGPT2-mediated loosening of cell-matrix contacts may induce endothelial cell apoptosis with consequent vascular regression. In concert with VEGF, it may facilitate endothelial cell migration and proliferation, thus serving as a permissive angiogenic signal. Interacts with TEK/TIE2, competing for the same binding site as ANGPT1. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 8p23.1
Cellular Component: cell projection; extracellular region; extracellular space; nucleus; plasma membrane
Molecular Function: metal ion binding; protein binding; receptor binding; receptor tyrosine kinase binding
Biological Process: angiogenesis; germ cell development; leukocyte migration; maternal process involved in female pregnancy; negative regulation of angiogenesis; negative regulation of blood vessel endothelial cell migration; negative regulation of positive chemotaxis; organ regeneration; positive regulation of angiogenesis; response to activity; response to glucose stimulus; response to hypoxia; response to mechanical stimulus; response to organic cyclic compound; response to radiation; signal transduction; Tie signaling pathway
Reference #:  O15123 (UniProtKB)
Alt. Names/Synonyms: AGPT2; ANG-2; ANG2; angiopoietin 2; Angiopoietin-2; angiopoietin-2a; angiopoietin-2B; ANGP2; ANGPT2; Tie2-ligand
Gene Symbols: ANGPT2
Molecular weight: 56,919 Da
Basal Isoelectric point: 5.41  Predict pI for various phosphorylation states
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Protein Structure Not Found.
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