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Mer a proto-oncogene receptor tyrosine-protein kinase of the Axl family. Binds several ligands including LGALS3, Tubby, TULP1 or GAS6. Regulates many physiological processes including cell survival, migration, differentiation, and phagocytosis of apoptotic cells (efferocytosis). Functions in the retinal pigment epithelium (RPE) as a regulator of rod outer segments fragments phagocytosis. Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response by activating STAT1, which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3. Interacts (upon activation) with TNK2; stimulates TNK2 autophosphorylation. Interacts with VAV1 in a phosphotyrosine-independent manner. Not expressed in normal B- and T-lymphocytes but is expressed in numerous neoplastic B- and T-cell lines. Highly expressed in testis, ovary, prostate, lung, and kidney, with lower expression in spleen, small intestine, colon, and liver. Defects are a cause of retinitis pigmentosa, a group of human diseases that leads to degeneration of retinal photoreceptor cells. Note: This description may include information from UniProtKB.
Protein type: Axl family; EC; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor); TK group
Chromosomal Location of Human Ortholog: 2q13
Cellular Component: cytoplasm; extracellular space; integral to plasma membrane; plasma membrane
Molecular Function: protein binding
Biological Process: cell surface receptor linked signal transduction; cell-cell signaling; leukocyte migration; phagocytosis; positive regulation of phagocytosis; protein amino acid phosphorylation
Disease: Retinitis Pigmentosa 38
Reference #:  Q12866 (UniProtKB)
Alt. Names/Synonyms: c-mer; c-mer proto-oncogene tyrosine kinase; MER; MER receptor tyrosine kinase; MERTK; MGC133349; Proto-oncogene c-Mer; Receptor tyrosine kinase MerTK; RP38; STK kinase; Tyrosine-protein kinase Mer
Gene Symbols: MERTK
Molecular weight: 110,249 Da
Basal Isoelectric point: 5.51  Predict pI for various phosphorylation states
CST Pathways:  Hippo Signaling  |  Tyrosine Kinases & Substrates
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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