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Ack a tyrosine kinase that binds Cdc42 in its GTP-bound form and inhibits both the intrinsic and GTPase-activating protein (GAP)-stimulated GTPase activity of Cdc42. This binding is mediated by a unique sequence of 47 amino acids C-terminal to an SH3 domain. May be involved in a regulatory mechanism that sustains the GTP-bound active form of Cdc42 and which is directly linked to a tyrosine phosphorylation signal transduction pathway. Amplification in primary tumors correlates with metastatic potential . Two differentially spliced isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: Ack family; EC; EC; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor); TK group
Chromosomal Location of Human Ortholog: 3q29
Cellular Component: clathrin-coated vesicle; coated pit; cytoplasm; endosome; extrinsic to internal side of plasma membrane; membrane; nucleus; plasma membrane
Molecular Function: epidermal growth factor receptor binding; GTPase inhibitor activity; identical protein binding; non-membrane spanning protein tyrosine kinase activity; protein binding; protein serine/threonine/tyrosine kinase activity; protein-tyrosine kinase activity; ubiquitin protein ligase binding; WW domain binding
Biological Process: cell differentiation; cell migration; cell surface receptor linked signal transduction; innate immune response; phosphorylation; positive regulation of peptidyl-tyrosine phosphorylation; regulation of cell proliferation; small GTPase mediated signal transduction; transmembrane receptor protein tyrosine kinase signaling pathway
Reference #:  Q07912 (UniProtKB)
Alt. Names/Synonyms: ACK; ACK-1; ACK1; Activated CDC42 kinase 1; activated Cdc42-associated kinase 1; activated p21cdc42Hs kinase; FLJ44758; FLJ45547; p21cdc42Hs; TNK2; Tyrosine kinase non-receptor protein 2; tyrosine kinase, non-receptor, 2
Gene Symbols: TNK2
Molecular weight: 114,569 Da
Basal Isoelectric point: 6.84  Predict pI for various phosphorylation states
CST Pathways:  Tyrosine Kinases & Substrates
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Protein Structure Not Found.
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