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FAAH Degrades bioactive fatty acid amides like oleamide, the endogenous cannabinoid, anandamide and myristic amide to their corresponding acids, thereby serving to terminate the signaling functions of these molecules. Hydrolyzes polyunsaturated substrate anandamide preferentially as compared to monounsaturated substrates. Homodimer. Highly expressed in the brain, small intestine, pancreas, skeletal muscle and testis. Also expressed in the kidney, liver, lung, placenta and prostate. Inhibited by O-aryl carbamates and alpha-keto heterocytes. Belongs to the amidase family. Note: This description may include information from UniProtKB.
Protein type: EC; Hydrolase; Membrane protein, integral
Chromosomal Location of Human Ortholog: 1p33
Cellular Component: endoplasmic reticulum membrane
Molecular Function: fatty acid amide hydrolase activity; protein binding
Biological Process: arachidonic acid metabolic process; fatty acid catabolic process
Disease: Polysubstance Abuse, Susceptibility To
Reference #:  O00519 (UniProtKB)
Alt. Names/Synonyms: Anandamide amidohydrolase 1; FAAH; FAAH-1; FAAH1; fatty acid amide hydrolase; Fatty-acid amide hydrolase 1; MGC102823; MGC138146; Oleamide hydrolase 1
Gene Symbols: FAAH
Molecular weight: 63,066 Da
Basal Isoelectric point: 7.82  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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