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ACLY ATP citrate-lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. Has a central role in de novo lipid synthesis. In nervous tissue it may be involved in the biosynthesis of acetylcholine. Homotetramer. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Carbohydrate Metabolism - citrate (TCA) cycle; EC; Lyase; Transferase
Chromosomal Location of Human Ortholog: 17q21.2
Cellular Component: citrate lyase complex; cytosol; extracellular region; membrane; nucleoplasm; plasma membrane
Molecular Function: ATP binding; ATP citrate synthase activity; protein binding
Biological Process: acetyl-CoA biosynthetic process; acyl-CoA biosynthetic process; cholesterol biosynthetic process; citrate metabolic process; fatty acid biosynthetic process; lipid biosynthetic process; neutrophil degranulation; oxaloacetate metabolic process; positive regulation of cellular metabolic process
Reference #:  P53396 (UniProtKB)
Alt. Names/Synonyms: ACL; ACLY; ATP citrate lyase; ATP-citrate (pro-S-)-lyase; ATP-citrate synthase; ATPCL; Citrate cleavage enzyme; CLATP
Gene Symbols: ACLY
Molecular weight: 120,839 Da
Basal Isoelectric point: 6.95  Predict pI for various phosphorylation states
CST Pathways:  Insulin Receptor Signaling  |  Warburg Effect
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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