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ITGA5 Integrin alpha-5/beta-1 is a receptor for fibronectin and fibrinogen. It recognizes the sequence R-G-D in its ligands. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions. Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of an heavy and a light chain linked by a disulfide bond. Alpha-5 associates with beta-1. Interacts with HPS5 and NISCH. Interacts with RAB21 and COMP. Interacts with HIV- 1 Tat. Belongs to the integrin alpha chain family. Note: This description may include information from UniProtKB.
Protein type: Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 12q13.13
Cellular Component: cell surface; cytoplasmic vesicle; endoplasmic reticulum; external side of plasma membrane; focal adhesion; Golgi apparatus; integrin complex; intercellular junction; plasma membrane; ruffle; synapse
Molecular Function: epidermal growth factor receptor binding; integrin binding; metal ion binding; platelet-derived growth factor receptor binding; protein binding; vascular endothelial growth factor receptor 2 binding; viral receptor activity
Biological Process: angiogenesis; cell adhesion; cell adhesion mediated by integrin; cell-cell adhesion mediated by integrin; cell-substrate adhesion; cell-substrate junction assembly; entry of virus into host cell; extracellular matrix organization; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules; heterotypic cell-cell adhesion; integrin-mediated signaling pathway; leukocyte adhesion; leukocyte migration; memory; positive regulation of cell migration; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of vascular endothelial growth factor receptor signaling pathway; wound healing, spreading of epidermal cells
Reference #:  P08648 (UniProtKB)
Alt. Names/Synonyms: CD49 antigen-like family member E; CD49e; Fibronectin receptor subunit alpha; fibronectin receptor, alpha subunit; FNRA; Integrin alpha-5; Integrin alpha-5 heavy chain; Integrin alpha-5 light chain; Integrin alpha-F; integrin, alpha 5 (fibronectin receptor, alpha polypeptide); ITA5; ITGA5; very late activation protein 5, alpha subunit; VLA-5; VLA5A
Gene Symbols: ITGA5
Molecular weight: 114,536 Da
Basal Isoelectric point: 5.5  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  GPCR Signaling to MAPKs  |  Growth And Differentiation Control by MAPKs  |  PI3K/Akt Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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