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NBR1 Acts probably as a receptor for selective autophagosomal degradation of ubiquitinated targets. Homooligomer and heterooligomer. Interacts with TRIM55. Interacts with SQSTM1, titin/TTN, RNF29, USP8, SQSTM1, MAP1LC3A, MAP1LC3B, MAP1LC3C, GABARAP, GABARAPL1 and GABARAPL2. Binds to ubiquitin and ubiquitinated proteins. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Ubiquitin conjugating system
Chromosomal Location of Human Ortholog: 17q21.31
Cellular Component: autophagic vacuole; cytosol; intracellular membrane-bound organelle; late endosome; membrane; mitochondrion; nuclear body; nucleoplasm
Molecular Function: mitogen-activated protein kinase binding; protein binding; ubiquitin binding
Biological Process: macroautophagy; negative regulation of osteoblast differentiation; protein oligomerization; regulation of bone mineralization; regulation of stress-activated MAPK cascade
Reference #:  Q14596 (UniProtKB)
Alt. Names/Synonyms: 1A1-3B; 1A13B; Cell migration-inducing gene 19 protein; FLJ55359; FLJ98272; KIAA0049; M17S2; Membrane component chromosome 17 surface marker 2; MIG19; migration-inducing protein 19; NBR1; neighbor of BRCA1 gene 1; Neighbor of BRCA1 gene 1 protein; Next to BRCA1 gene 1 protein; Protein 1A1-3B
Gene Symbols: NBR1
Molecular weight: 107,413 Da
Basal Isoelectric point: 5.03  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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