Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
Home | Login
About PhosphoSiteUsing PhosphoSiteprivacy & cookiesCuration ProcessContact
logos LINCs Logo Mt Sinai Logo NIH Logo NCI Logo
Search / Browse Functions
Protein Page:

MCL1 a myeloid cell leukemia protein of the Bcl-2 family of proteins. Two alternatively spliced transcripts encoding distinct isoforms have been identified. The longer gene product (isoform 1) enhances cell survival by inhibiting apoptosis while the alternatively spliced shorter gene product (isoform 2) promotes apoptosis and is death-inducing. Note: This description may include information from UniProtKB.
Protein type: Apoptosis; Channel, misc.; Inhibitor; Membrane protein, integral; Mitochondrial
Chromosomal Location of Human Ortholog: 1q21.2
Cellular Component: cytoplasm; cytosol; membrane; mitochondrial outer membrane; mitochondrion; nucleus
Molecular Function: BH3 domain binding; protein binding; protein channel activity; protein heterodimerization activity; protein homodimerization activity
Biological Process: DNA damage response, signal transduction resulting in induction of apoptosis; negative regulation of apoptosis; negative regulation of autophagy; response to cytokine stimulus
Reference #:  Q07820 (UniProtKB)
Alt. Names/Synonyms: Bcl-2-like protein 3; Bcl-2-related protein EAT/mcl1; Bcl2-L-3; BCL2L3; EAT; Induced myeloid leukemia cell differentiation protein Mcl-1; Mcl-1; MCL1; mcl1/EAT; MCL1L; MCL1S; MGC104264; MGC1839; myeloid cell leukemia ES; myeloid cell leukemia sequence 1 (BCL2-related); myeloid cell leukemia sequence 1, isoform 1; TM
Gene Symbols: MCL1
Molecular weight: 37,337 Da
Basal Isoelectric point: 5.51  Predict pI for various phosphorylation states
CST Pathways:  Apoptosis Regulation  |  IL6 Signaling  |  Inhibition of Apoptosis  |  Mitochondrial Control of Apoptosis
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below


Protein Structure Not Found.
Download PyMol Script
Download ChimeraX Script

STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Scansite  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein