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KPNB1 a nuclear import protein nuclear protein import that functions either in association with an adapter protein, like an importin-alpha subunit, which binds to nuclear localization signals (NLS) in cargo substrates, or by acting as autonomous nuclear transport receptor. Acting autonomously, serves itself as NLS receptor. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re- exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Mediates autonomously the nuclear import of ribosomal proteins RPL23A, RPS7 and RPL5. Binds to a beta-like import receptor binding (BIB) domain of RPL23A. In association with IPO7 mediates the nuclear import of H1 histone. In vitro, mediates nuclear import of H2A, H2B, H3 and H4 histones. In case of HIV-1 infection, binds and mediates the nuclear import of HIV-1 Rev. Imports PRKCI into the nucleus. Forms a complex with an importin alpha subunit. Forms a heterodimer with IPO7. Interacts with IPO7, SNUPN, RPL23A and XPO1. Two isoforms of the human protein have been reported. Belongs to the importin beta family. Note: This description may include information from UniProtKB.
Protein type: Karyopherin; Nuclear import
Chromosomal Location of Human Ortholog: 17q21.32
Cellular Component: cytoplasm; cytosol; extracellular region; membrane; nuclear envelope; nuclear membrane; nuclear pore; nucleoplasm
Molecular Function: enzyme binding; nuclear localization sequence binding; protein binding; protein domain specific binding; protein transporter activity; RNA binding; zinc ion binding
Biological Process: astral microtubule organization and biogenesis; DNA fragmentation during apoptosis; establishment of mitotic spindle localization; establishment of protein localization; mitotic chromosome movement towards spindle pole; mitotic metaphase plate congression; modification by virus of host cellular process; neutrophil degranulation; NLS-bearing substrate import into nucleus; protein import into nucleus; protein import into nucleus, translocation; Ran protein signal transduction; regulation of cholesterol biosynthetic process; ribosomal protein import into nucleus
Reference #:  Q14974 (UniProtKB)
Alt. Names/Synonyms: IMB1; Impnb; importin 1; importin 90; importin beta-1 subunit; Importin subunit beta-1; Importin-90; IPO1; IPOB; karyopherin (importin) beta 1; Karyopherin subunit beta-1; KPNB1; MGC2155; MGC2156; MGC2157; NTF97; Nuclear factor p97; Pore targeting complex 97 kDa subunit; PTAC97
Gene Symbols: KPNB1
Molecular weight: 97,170 Da
Basal Isoelectric point: 4.68  Predict pI for various phosphorylation states
CST Pathways:  ErbB/HER Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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