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SPFH2 Component of the ERLIN1/ERLIN2 complex which mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs). Also involved in ITPR1 degradation by the ERAD pathway. Interacts with activated ITPR1, independently of the degree of ITPR1 polyubiquitination. Forms a heteromeric complex with ERLIN1. Ubiquitous. Belongs to the band 7/mec-2 family. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Endoplasmic reticulum; Membrane protein, integral
Chromosomal Location of Human Ortholog: 8p11.23
Cellular Component: cytosol; endoplasmic reticulum; endoplasmic reticulum membrane; lipid raft; plasma membrane; protein complex
Molecular Function: cholesterol binding; protein binding; protein-tyrosine kinase activity; ubiquitin protein ligase binding
Biological Process: ER-associated protein catabolic process; negative regulation of cholesterol biosynthetic process; negative regulation of fatty acid biosynthetic process; SREBP-mediated signaling pathway; transmembrane transport
Disease: Spastic Paraplegia 18, Autosomal Recessive
Reference #:  O94905 (UniProtKB)
Alt. Names/Synonyms: C8orf2; Endoplasmic reticulum lipid raft-associated protein 2; ER lipid raft associated 2; Erlin-2; ERLIN2; ERLN2; MGC87072; NET32; SPFH domain family, member 2; SPFH domain-containing protein 2; SPFH2; Stomatin-prohibitin-flotillin-HflC/K domain-containing protein 2
Gene Symbols: ERLIN2
Molecular weight: 37,840 Da
Basal Isoelectric point: 5.47  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

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