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IRF6 Probable DNA-binding transcriptional activator. Key determinant of the keratinocyte proliferation-differentiation switch involved in appropriate epidermal development. Plays a role in regulating mammary epithelial cell proliferation. May regulate WDR65 transcription. Interacts with SERPINB5. Expressed in normal mammary epithelial cells. Expression is reduced or absent in breast carcinomas. Belongs to the IRF family. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Transcription factor
Chromosomal Location of Human Ortholog: 1q32.2
Cellular Component: cytoplasm; cytosol; nucleus
Molecular Function: DNA binding; protein binding; transcription factor activity
Biological Process: cell cycle arrest; negative regulation of cell proliferation; positive regulation of transcription, DNA-dependent
Disease: Orofacial Cleft 6, Susceptibility To; Popliteal Pterygium Syndrome; Van Der Woude Syndrome 1
Reference #:  O14896 (UniProtKB)
Alt. Names/Synonyms: Interferon regulatory factor 6; IRF-6; IRF6; LPS; OFC6; PIT; PPS; VWS
Gene Symbols: IRF6
Molecular weight: 53,130 Da
Basal Isoelectric point: 5.18  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

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