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Protein Page:
CDC42 iso1

CDC42 iso1 a small GTPase of the Rho-subfamily, which regulates signaling pathways that control diverse cellular functions including cell morphology, migration, endocytosis and cell cycle progression. Causes the formation of thin, actin-rich surface projections called filopodia. The oncoprotein Dbl specifically catalyzes the dissociation of GDP from this protein. Regulate actin polymerization through its direct binding to Neural Wiskott-Aldrich syndrome protein (N-WASP), which subsequently activates Arp2/3 complex. Interacts with DOCK9 which activates it by exchanging GDP for GTP. Interacts with PARD6A, PARD6B and PARD6G in a GTP-dependent manner. Part of a complex with PARD3, PARD6A or PARD6B and PRKCI or PRKCZ. Interacts with CDC42EP4.Alternative splicing of this gene results in at least two transcript variants. Note: This description may include information from UniProtKB.
Protein type: G protein; G protein, monomeric; G protein, monomeric, Rho; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 1p36.12
Cellular Component: cell soma; cytoplasm; cytosol; dendritic spine; endoplasmic reticulum membrane; filopodium; focal adhesion; Golgi membrane; Golgi transport complex; membrane; midbody; neuron projection; plasma membrane; spindle midzone
Molecular Function: apolipoprotein A-I receptor binding; GBD domain binding; GTP binding; GTPase activity; identical protein binding; protein binding; protein kinase binding; thioesterase binding
Biological Process: actin cytoskeleton organization and biogenesis; blood coagulation; ephrin receptor signaling pathway; establishment and/or maintenance of cell polarity; establishment of Golgi localization; Golgi organization and biogenesis; macrophage differentiation; negative regulation of epidermal growth factor receptor signaling pathway; negative regulation of protein complex assembly; positive regulation of cell growth; positive regulation of cytokinesis; positive regulation of filopodium formation; positive regulation of muscle cell differentiation; positive regulation of pseudopodium formation; positive regulation of stress fiber formation; regulation of attachment of spindle microtubules to kinetochore; regulation of filopodium formation; regulation of small GTPase mediated signal transduction; regulation of stress fiber formation; substantia nigra development; T cell costimulation; vascular endothelial growth factor receptor signaling pathway
Disease: Takenouchi-kosaki Syndrome
Reference #:  P60953-1 (UniProtKB)
Alt. Names/Synonyms: CDC42; CDC42Hs; Cell division control protein 42 homolog; cell division cycle 42 (GTP binding protein, 25kDa); dJ224A6.1.1 (cell division cycle 42 (GTP-binding protein, 25kD)); dJ224A6.1.2 (cell division cycle 42 (GTP-binding protein, 25kD)); G25K; G25K GTP-binding protein; growth-regulating protein; GTP-binding protein, 25kD; small GTP binding protein CDC42
Gene Symbols: CDC42
Molecular weight: 21,311 Da
Basal Isoelectric point: 5.76  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  Adherens Junction Dynamics  |  B Cell Receptor Signaling  |  ErbB/HER Signaling  |  Microtubule Dynamics  |  SAPK/JNK Signaling Cascades  |  T Cell Receptor Signaling  |  TGF-ß Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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CDC42 iso1

Protein Structure Not Found.
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