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CD36 Seems to have numerous potential physiological functions. Binds to collagen, thrombospondin, anionic phospholipids and oxidized LDL. May function as a cell adhesion molecule. Directly mediates cytoadherence of Plasmodium falciparum parasitized erythrocytes. Binds long chain fatty acids and may function in the transport and/or as a regulator of fatty acid transport. Receptor for thombospondins, THBS1 AND THBS2, mediating their antiangiogenic effects. Defects in CD36 are the cause of platelet glycoprotein IV deficiency (PG4D)[MIM:608404]; also known as CD36 deficiency. Platelet glycoprotein IV deficiency can be divided into 2 subgroups. The type I phenotype is characterized by platelets and monocytes/macrophages exhibiting complete CD36 deficiency. The type II phenotype lacks the surface expression of CD36 in platelets, but expression in monocytes/macrophages is near normal. Genetic variations in CD36 are associated with susceptibility to coronary heart disease type 7 (CHDS7). Belongs to the CD36 family. Note: This description may include information from UniProtKB.
Protein type: Cell adhesion; Membrane protein, integral; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 7q21.11
Cellular Component: apical plasma membrane; brush border membrane; cell surface; external side of plasma membrane; extracellular space; Golgi apparatus; integral component of plasma membrane; intracellular; membrane; membrane raft; phagocytic vesicle; plasma membrane; platelet alpha granule membrane; receptor complex
Molecular Function: amyloid-beta binding; high-density lipoprotein particle binding; lipid binding; low-density lipoprotein particle binding; low-density lipoprotein receptor activity; protein binding; scavenger receptor activity; transforming growth factor beta binding
Biological Process: antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; apoptotic cell clearance; blood coagulation; cell adhesion; cell surface receptor signaling pathway; cGMP-mediated signaling; cholesterol transport; defense response to Gram-positive bacterium; elevation of cytosolic calcium ion concentration; interleukin-1 beta secretion; intestinal absorption; intestinal cholesterol absorption; lipid metabolic process; lipid storage; lipoprotein transport; low density lipoprotein mediated signaling; MyD88-dependent toll-like receptor signaling pathway; negative regulation of transcription factor import into nucleus; negative regulation of transcription from RNA polymerase II promoter; neutrophil degranulation; nitric oxide mediated signal transduction; phagocytosis, recognition; platelet degranulation; positive regulation of blood coagulation; positive regulation of cell-matrix adhesion; positive regulation of I-kappaB kinase/NF-kappaB signaling; positive regulation of interleukin-12 production; positive regulation of interleukin-6 production; positive regulation of NF-kappaB transcription factor activity; positive regulation of nitric oxide biosynthetic process; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of phagocytosis, engulfment; positive regulation of tumor necrosis factor production; receptor internalization; receptor-mediated endocytosis; regulation of lipid metabolic process; regulation of protein heterodimerization activity; regulation of toll-like receptor signaling pathway; response to lipid; sensory perception of taste; toll-like receptor signaling pathway; triglyceride transport
Disease: Coronary Heart Disease, Susceptibility To, 7; Malaria, Susceptibility To; Platelet Glycoprotein Iv Deficiency
Reference #:  P16671 (UniProtKB)
Alt. Names/Synonyms: CD36; CD36 antigen (collagen type I receptor, thrombospondin receptor); CD36 molecule (thrombospondin receptor); CHDS7; cluster determinant 36; FAT; Fatty acid translocase; Glycoprotein IIIb; GP3B; GP4; GPIIIB; GPIV; Leukocyte differentiation antigen CD36; PAS IV; PAS-4; PAS-4 protein; PASIV; Platelet collagen receptor; Platelet glycoprotein 4; Platelet glycoprotein IV; SCARB3; scavenger receptor class B, member 3; Thrombospondin receptor
Gene Symbols: CD36
Molecular weight: 53,053 Da
Basal Isoelectric point: 8.19  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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