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MTMR14 Lipid phosphatase which efficiently dephosphorylates phosphatidylinositol 3-phosphate (PtdIns3P) and PtdIns(3,5)P2; inactive toward PtdIns4P, PtdIns(3,4)P2, PtdIns(4,5)P2 and PtdIns(3,4,5)P3. Expressed in various tissues, including heart, skeletal muscle, placenta, liver, lung, kidney and pancreas. Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: EC 3.1.3.-; Phosphatase, lipid; Protein phosphatase, tyrosine (non-receptor)
Chromosomal Location of Human Ortholog: 3p25.3
Cellular Component: cytosol; perinuclear region of cytoplasm; ruffle
Molecular Function: phosphatidylinositol-3-phosphatase activity; protein binding; protein serine/threonine phosphatase activity
Biological Process: macroautophagy; phosphatidylinositol biosynthetic process
Disease: Myopathy, Centronuclear, 1
Reference #:  Q8NCE2 (UniProtKB)
Alt. Names/Synonyms: C3orf29; egg-derived tyrosine phosphatase homolog; FLJ11546; FLJ22405; FLJ46453; FLJ90311; HCV NS5A-transactivated protein 4 splice variant A-binding protein 1; hJumpy; jumpy; MTMR14; MTMRE; myotubularin related protein 14; Myotubularin-related protein 14; NS5ATP4ABP1
Gene Symbols: MTMR14
Molecular weight: 72,203 Da
Basal Isoelectric point: 5.85  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

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