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Protein Page:

Myt1 a dual specificity protein kinase of the WEE family. Preferentially phosphorylates and inactivates cell division cycle 2 protein (CDC2), and thus negatively regulates cell cycle G2/M transition. This kinase is associated with the membrane throughout the cell cycle. Its activity is highly regulated during the cell cycle. Alternative splice-variant isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC; Kinase, protein; Other group; Protein kinase, Other; Protein kinase, dual-specificity (non-receptor); WEE family
Chromosomal Location of Human Ortholog: 16p13.3
Cellular Component: cytosol; endoplasmic reticulum; endoplasmic reticulum membrane; Golgi apparatus; Golgi membrane; membrane; nucleolus; nucleoplasm; nucleus
Molecular Function: ATP binding; kinase activity; metal ion binding; protein binding; protein kinase activity; protein serine/threonine kinase activity
Biological Process: G2/M transition of mitotic cell cycle; mitotic cell cycle; negative regulation of phosphatase activity; protein amino acid phosphorylation; regulation of cell cycle; regulation of cyclin-dependent protein kinase activity; regulation of mitotic nuclear division
Reference #:  Q99640 (UniProtKB)
Alt. Names/Synonyms: DKFZp547K1610; FLJ20093; Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase; MYT1; Myt1 kinase; PKMYT1; PMYT1; protein kinase Myt1; protein kinase, membrane associated tyrosine/threonine 1
Gene Symbols: PKMYT1
Molecular weight: 54,521 Da
Basal Isoelectric point: 6.48  Predict pI for various phosphorylation states
CST Pathways:  G2/M DNA Damage Checkpoint  |  Growth And Differentiation Control by MAPKs  |  PI3K/Akt Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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