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ABCG2 Xenobiotic transporter that may play an important role in the exclusion of xenobiotics from the brain. May be involved in brain-to-blood efflux. Appears to play a major role in the multidrug resistance phenotype of several cancer cell lines. When overexpressed, the transfected cells become resistant to mitoxantrone, daunorubicin and doxorubicin, display diminished intracellular accumulation of daunorubicin, and manifest an ATP- dependent increase in the efflux of rhodamine 123. Monomer or homodimer; disulfide-linked. Up-regulated in brain tumors. Highly expressed in placenta. Low expression in small intestine, liver and colon. Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ABC family; Transporter, iron
Chromosomal Location of Human Ortholog: 4q22.1
Cellular Component: apical plasma membrane; integral to membrane; nucleus; plasma membrane; receptor complex
Molecular Function: ATPase activity, coupled to transmembrane movement of substances; cholesterol transporter activity; heme transporter activity; protein binding; protein homodimerization activity; transporter activity; xenobiotic-transporting ATPase activity
Biological Process: cellular iron ion homeostasis; cholesterol efflux; response to drug; transport; urate metabolic process
Disease: Blood Group, Junior System; Uric Acid Concentration, Serum, Quantitative Trait Locus 1
Reference #:  Q9UNQ0 (UniProtKB)
Alt. Names/Synonyms: ABC transporter; ABC15; ABCG2; ABCP; ATP-binding cassette sub-family G member 2; ATP-binding cassette transporter G2; ATP-binding cassette, sub-family G (WHITE), member 2; BCRP; BCRP1; BMDP; Breast cancer resistance protein; CD338; CDw338; EST157481; MGC102821; mitoxantrone resistance protein; Mitoxantrone resistance-associated protein; MRX; MXR; MXR1; placenta specific MDR protein; Placenta-specific ATP-binding cassette transporter
Gene Symbols: ABCG2
Molecular weight: 72,314 Da
Basal Isoelectric point: 8.91  Predict pI for various phosphorylation states
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