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AGR2 Required for MUC2 post-transcriptional synthesis and secretion. May play a role in the production of mucus by intestinal cells. Proto-oncogene that may play a role in cell migration, cell differentiation and cell growth. Interacts with LYPD3 and DAG1 (alphaDAG1). Interacts with MUC2; disulfide-linked. Expressed strongly in trachea, lung, stomach, colon, prostate and small intestine. Expressed weakly in pituitary gland, salivary gland, mammary gland, bladder, appendix, ovary, fetal lung, uterus, pancreas, kidney, fetal kidney, testis, placenta, thyroid gland and in estrogen receptor (ER)-positive breast cancer cell lines. Belongs to the AGR family. Note: This description may include information from UniProtKB.
Protein type: Oncoprotein; Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 7p21.1
Cellular Component: endoplasmic reticulum; extracellular space
Molecular Function: epidermal growth factor receptor binding; protein binding; protein homodimerization activity
Biological Process: cell differentiation; digestive tract morphogenesis; positive regulation of developmental growth; positive regulation of epidermal growth factor receptor signaling pathway
Reference #:  O95994 (UniProtKB)
Alt. Names/Synonyms: AG-2; AG2; AGR2; anterior gradient 2 homolog; anterior gradient homolog 2 (Xenopus laevis); Anterior gradient protein 2 homolog; GOB-4; hAG-2; HPC8; PDIA17; protein disulfide isomerase family A, member 17; secreted cement gland homolog; Secreted cement gland protein XAG-2 homolog; XAG-2
Gene Symbols: AGR2
Molecular weight: 19,979 Da
Basal Isoelectric point: 9.03  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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