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ABCC2 Mediates hepatobiliary excretion of numerous organic anions. May function as a cellular cisplatin transporter. Found on the apical membrane of polarized cells in liver, kidney and intestine. The highest expression is found in liver. Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ABC family
Chromosomal Location of Human Ortholog: 10q24.2
Cellular Component: apical plasma membrane; cell surface; integral to plasma membrane; plasma membrane
Molecular Function: anion transmembrane-transporting ATPase activity; ATPase activity, coupled to transmembrane movement of substances; bilirubin transmembrane transporter activity; organic anion transmembrane transporter activity; protein binding
Biological Process: cellular response to hormone stimulus; transmembrane transport; transport
Disease: Dubin-johnson Syndrome
Reference #:  Q92887 (UniProtKB)
Alt. Names/Synonyms: ABC30; ABCC2; ATP-binding cassette sub-family C member 2; ATP-binding cassette, sub-family C (CFTR/MRP), member 2; Canalicular multidrug resistance protein; Canalicular multispecific organic anion transporter 1; CMOAT; CMOAT1; CMRP; DJS; KIAA1010; MRP2; Multidrug resistance-associated protein 2
Gene Symbols: ABCC2
Molecular weight: 174,207 Da
Basal Isoelectric point: 8.57  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

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