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Geminin Inhibits DNA replication by preventing the incorporation of MCM complex into pre-replication complex (pre-RC). It is degraded during the mitotic phase of the cell cycle. Its destruction at the metaphase-anaphase transition permits replication in the succeeding cell cycle. Homotetramer. Interacts with CDT1; inhibits binding of the MCM complex to origins of replication. Interacts with IDAS; targets GMNN to the nucleus, prevents GMNN interaction with CDT1 and competes with IDAS homodimerization. Belongs to the geminin family. Note: This description may include information from UniProtKB.
Protein type: Cell cycle regulation; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 6p22.3
Cellular Component: cytoplasm; cytosol; nucleoplasm; nucleus
Molecular Function: chromatin binding; histone deacetylase binding; protein binding
Biological Process: negative regulation of cell cycle; negative regulation of DNA replication; negative regulation of transcription, DNA-dependent
Disease: Meier-gorlin Syndrome 6
Reference #:  O75496 (UniProtKB)
Alt. Names/Synonyms: Gem; GEMI; Geminin; geminin, DNA replication inhibitor; GMNN; RP3-369A17.3
Gene Symbols: GMNN
Molecular weight: 23,565 Da
Basal Isoelectric point: 4.93  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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