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CPLX1 Positively regulates a late step in synaptic vesicle exocytosis. Organizes the SNAREs into a cross-linked zigzag topology that, when interposed between the vesicle and plasma membranes, is incompatible with fusion, thereby preventing SNAREs from releasing neurotransmitters until an action potential arrives at the synapse. Also involved in glucose-induced secretion of insulin by pancreatic beta-cells. Belongs to the complexin/synaphin family. Note: This description may include information from UniProtKB.
Protein type: Vesicle
Chromosomal Location of Human Ortholog: 4p16.3
Cellular Component: cytosol
Biological Process: exocytosis; glutamate secretion; neurotransmitter secretion; regulation of exocytosis; synaptic transmission
Disease: Wolf-hirschhorn Syndrome
Reference #:  O14810 (UniProtKB)
Alt. Names/Synonyms: complexin 1; Complexin I; Complexin-1; CPLX1; CPX I; CPX-I; CPX1; synaphin 2; Synaphin-2
Gene Symbols: CPLX1
Molecular weight: 15,030 Da
Basal Isoelectric point: 4.93  Predict pI for various phosphorylation states
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