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RAD21 Cleavable component of the cohesin complex, involved in chromosome cohesion during cell cycle, in DNA repair, and in apoptosis. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At metaphase-anaphase transition, this protein is cleaved by separase/ESPL1 and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis. Also plays a role in apoptosis, via its cleavage by caspase-3/CASP3 or caspase-7/CASP7 during early steps of apoptosis: the C-terminal 64 kDa cleavage product may act as a nuclear signal to initiate cytoplasmic events involved in the apoptotic pathway. Cohesin complexes are composed of the SMC1 (SMC1A or SMC1B) and SMC3 heterodimer attached via their hinge domain, RAD21 which link them, and one STAG protein (STAG1, STAG2 or STAG3), which interacts with RAD21. Found in a complex with SMC1A, SMC3, CDCA5, PDS5A/APRIN and PDS5B/SCC-112. Interacts with PDS5B and WAPAL; the interaction is direct. Belongs to the rad21 family. Note: This description may include information from UniProtKB.
Chromosomal Location of Human Ortholog: 8q24.11
Cellular Component: chromosome; chromosome, pericentric region; cohesin complex; cytosol; membrane; nucleoplasm
Molecular Function: chromatin binding; protein binding
Biological Process: DNA recombination; double-strand break repair; meiotic recombination; positive regulation of sister chromatid cohesion; regulation of transcription from RNA polymerase II promoter; sister chromatid cohesion
Disease: Cornelia De Lange Syndrome 4
Reference #:  O60216 (UniProtKB)
Alt. Names/Synonyms: Double-strand-break repair protein rad21 homolog; FLJ25655; FLJ40596; hHR21; HR21; HRAD21; KIAA0078; MCD1; Nuclear matrix protein 1; NXP-1; NXP1; protein involved in DNA double-strand break repair; RAD21; RAD21 homolog (S. pombe); SCC1; SCC1 homolog
Gene Symbols: RAD21
Molecular weight: 71,690 Da
Basal Isoelectric point: 4.54  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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