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SPFH1 Component of the ERLIN1/ERLIN2 complex which mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs). Belongs to the band 7/mec-2 family. Forms a heteromeric complex with ERLIN2. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral
Chromosomal Location of Human Ortholog: 10q24.31
Cellular Component: endoplasmic reticulum; endoplasmic reticulum membrane; protein complex
Molecular Function: cholesterol binding; protein binding
Biological Process: ER-associated protein catabolic process; negative regulation of cholesterol biosynthetic process; negative regulation of fatty acid biosynthetic process; SREBP-mediated signaling pathway; transmembrane transport
Disease: Spastic Paraplegia 62, Autosomal Recessive
Reference #:  O75477 (UniProtKB)
Alt. Names/Synonyms: Band_7 23-211 Keo4 (Interim) similar to C.elegans protein C42C1.9; C10orf69; Endoplasmic reticulum lipid raft-associated protein 1; ER lipid raft associated 1; Erlin-1; ERLIN1; ERLN1; KE04; KEO4; Protein KE04; SPFH domain family, member 1; SPFH domain-containing protein 1; SPFH1; Stomatin-prohibitin-flotillin-HflC/K domain-containing protein 1
Gene Symbols: ERLIN1
Molecular weight: 38,926 Da
Basal Isoelectric point: 7.67  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

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