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PXN a multi-domain cytoskeletal protein involved in actin-membrane attachment that localizes primarily to focal adhesion sites to the extracellular matrix. Phosphorylated by focal adhesion kinase (FAK) and is a component of integrin signaling. Its phosphorylation provides docking sites for recruitment of signaling molecules to focal adhesions. Binds in vitro to vinculin as well as to the SH3 domain of c-SRC and, when tyrosine phosphorylated, to the Crk SH2 domain. Interacts with GIT1, NUDT16L1/SDOS, PARVA and TGFB1I1. Component of cytoplasmic complexes, which also contain GIT1, ARHGEF6 and PAK1. Binds DDEF2. Interacts with unphosphorylated ITGA4. Interacts with RNF5.Three alternatively-spliced isoforms have been described. Isoform beta binds to focal adhesion kinase but weakly to vinculin. Isoform gamma binds to vinculin but only weakly to focal adhesion kinase. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold; Cell adhesion; Cytoskeletal; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 5 F|5 56.1 cM
Cellular Component: cytosol; focal adhesion; lamellipodium; leading edge; plasma membrane; stress fiber
Molecular Function: beta-catenin binding; BH4 domain binding; integrin binding; protein binding; protein complex binding; protein kinase binding; receptor signaling complex scaffold activity; ubiquitin protein ligase binding; vinculin binding
Biological Process: activation of MAPK activity; branching morphogenesis of a tube; cell motility; cytoskeleton organization and biogenesis; focal adhesion formation; integrin-mediated signaling pathway; lamellipodium biogenesis; peptidyl-tyrosine phosphorylation; positive regulation of protein kinase activity; regulation of cell shape; transforming growth factor beta receptor signaling pathway
Reference #:  Q8VI36 (UniProtKB)
Alt. Names/Synonyms: AW108311; AW123232; OTTMUSP00000015574; OTTMUSP00000015575; Pax; PAXI; Paxillin; Pxn
Gene Symbols: Pxn
Molecular weight: 64,476 Da
Basal Isoelectric point: 5.67  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  ErbB/HER Signaling  |  Growth And Differentiation Control by MAPKs  |  PI3K/Akt Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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