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FOXO3A a transcription factors of the forkhead family. Contains 1 fork-head domain. May regulate apoptosis through control of genes necessary for cell death. Translocation of this gene with the MLL gene is associated with secondary acute leukemia. Note: This description may include information from UniProtKB.
Protein type: Autophagy; DNA-binding; Oncoprotein; Transcription factor
Chromosomal Location of Human Ortholog: 10 B2|10 22.79 cM
Cellular Component: cytoplasm; cytosol; membrane; mitochondrion; nucleoplasm; nucleus
Molecular Function: beta-catenin binding; chromatin DNA binding; DNA binding; protein binding; protein kinase binding; sequence-specific DNA binding; transcription factor activity
Biological Process: aging; antral ovarian follicle growth; brain morphogenesis; DNA damage response, signal transduction by p53 class mediator; glucose homeostasis; initiation of primordial ovarian follicle growth; negative regulation of neuron differentiation; negative regulation of transcription from RNA polymerase II promoter; oocyte maturation; ovulation from ovarian follicle; positive regulation of apoptosis; positive regulation of erythrocyte differentiation; positive regulation of neuron apoptosis; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; regulation of transcription from RNA polymerase II promoter; regulation of transcription, DNA-dependent; regulation of translation; tumor necrosis factor-mediated signaling pathway
Reference #:  Q9WVH4 (UniProtKB)
Alt. Names/Synonyms: 1110048B16Rik; 2010203A17Rik; C76856; Fkhr2; FKHRL1; forkhead box O3; Forkhead box O3a; Forkhead protein FKHR2; Foxo3; Foxo3a; OTTMUSP00000022929; OTTMUSP00000022930
Gene Symbols: Foxo3
Molecular weight: 71,064 Da
Basal Isoelectric point: 4.92  Predict pI for various phosphorylation states
CST Pathways:  B Cell Receptor Signaling  |  G1/S Checkpoint  |  GPCR Signaling to MAPKs  |  Growth And Differentiation Control by MAPKs  |  Insulin Receptor Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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