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ORC2 Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. ORC is composed of six subunits. In human, ORC is cell cycle-dependent regulated: it is sequentially assembled at the exit from anaphase of mitosis and disassembled as cells enter S phase. Interacts with DBF4. Interacts with MCM10. Belongs to the ORC2 family. Note: This description may include information from UniProtKB.
Protein type: DNA replication
Chromosomal Location of Human Ortholog: 2q33.1
Cellular Component: centrosome; heterochromatin; membrane; nuclear chromosome, telomeric region; nuclear origin of replication recognition complex; nucleoplasm; nucleus; origin recognition complex
Molecular Function: DNA replication origin binding; protein binding
Biological Process: DNA replication; DNA replication initiation; G1/S transition of mitotic cell cycle; negative regulation of transcription from RNA polymerase II promoter
Reference #:  Q13416 (UniProtKB)
Alt. Names/Synonyms: ORC2; ORC2L; origin of replication 2-like; origin recognition complex protein 2 homolog; Origin recognition complex subunit 2; origin recognition complex, subunit 2-like (yeast)
Gene Symbols: ORC2
Molecular weight: 65,972 Da
Basal Isoelectric point: 6.07  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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