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ACPP A non-specific tyrosine phosphatase that dephosphorylates a diverse number of substrates under acidic conditions (pH 4-6) including alkyl, aryl, and acyl orthophosphate monoesters and phosphorylated proteins. Has lipid phosphatase activity and inactivates lysophosphatidic acid in seminal plasma. Belongs to the histidine acid phosphatase family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Cofactor and Vitamin Metabolism - riboflavin; EC; EC; Motility/polarity/chemotaxis; Phosphatase
Chromosomal Location of Human Ortholog: 3q22.1
Cellular Component: extracellular space; intracellular; lysosomal membrane; nucleus; plasma membrane; vesicle membrane
Molecular Function: 5'-nucleotidase activity; acid phosphatase activity; identical protein binding; phosphoric monoester hydrolase activity; protein binding; protein homodimerization activity; thiamin phosphate phosphatase activity
Biological Process: adenosine metabolic process; dephosphorylation; neutrophil degranulation; positive regulation of adenosine receptor signaling pathway; protein homotetramerization; regulation of sensory perception of pain; thiamin metabolic process
Reference #:  P15309 (UniProtKB)
Alt. Names/Synonyms: acid phosphatase, prostate; ACP-3; ACP3; ACPP; PAP; PPAP; Prostatic acid phosphatase; prostatic acid phosphotase
Gene Symbols: ACPP
Molecular weight: 44,566 Da
Basal Isoelectric point: 5.83  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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