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TRPV3 Putative receptor-activated non-selective calcium permeant cation channel. It is activated by innocuous (warm) temperatures and shows an increased response at noxious temperatures greater than 39 degrees Celsius. Activation exhibits an outward rectification. May associate with TRPV1 and may modulate its activity. Is a negative regulator of hair growth and cycling: TRPV3-coupled signaling suppresses keratinocyte proliferation in hair follicles and induces apoptosis and premature hair follicle regression (catagen). May form a heteromeric channel with TRPV1. Interacts with TRPV1. Abundantly expressed in CNS. Widely expressed at low levels. Detected in dorsal root ganglion. Expressed in the keratinocyte layers of the outer root sheath and, to lesser extent, to the matrix of the hair follicles. Belongs to the transient receptor (TC 1.A.4) family. TrpV subfamily. TRPV3 sub-subfamily. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Channel, cation; Membrane protein, integral; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 17p13.2
Cellular Component: integral to plasma membrane; plasma membrane; receptor complex
Molecular Function: calcium channel activity
Biological Process: negative regulation of hair cycle
Disease: Palmoplantar Keratoderma, Mutilating, With Periorificial Keratotic Plaques; Palmoplantar Keratoderma, Nonepidermolytic, Focal 2
Reference #:  Q8NET8 (UniProtKB)
Alt. Names/Synonyms: Transient receptor potential cation channel subfamily V member 3; transient receptor potential cation channel, subfamily V, member 3; TRPV3; vanilloid receptor 3; Vanilloid receptor-like 3; vanilloid receptor-related osmotically activated channel protein; VRL-3; VRL3
Gene Symbols: TRPV3
Molecular weight: 90,636 Da
Basal Isoelectric point: 6.17  Predict pI for various phosphorylation states
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