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PAIP2 Acts as a repressor in the regulation of translation initiation of poly(A)-containing mRNAs. Its inhibitory activity on translation is mediated via its action on PABPC1. Displaces the interaction of PABPC1 with poly(A) RNA and competes with PAIP1 for binding to PABPC1. Its association with PABPC1 results in disruption of the cytoplasmic poly(A) RNP structure organization. Interacts with the second and third RRM domains and C- terminus regions of PABPC1 in a 2:1 stoichiometry. Belongs to the PAIP2 family. Note: This description may include information from UniProtKB.
Protein type: RNA-binding
Chromosomal Location of Human Ortholog: 5q31.2
Cellular Component: cytoplasm
Molecular Function: protein binding; translation repressor activity
Biological Process: negative regulation of translational initiation
Reference #:  Q9BPZ3 (UniProtKB)
Alt. Names/Synonyms: MGC72018; PABC1-interacting protein 2; PABP-interacting protein 2; PAIP-2; PAIP2; PAIP2A; poly(A) binding protein interacting protein 2; Poly(A)-binding protein-interacting protein 2; polyA-binding protein-interacting protein 2; Polyadenylate-binding protein-interacting protein 2
Gene Symbols: PAIP2
Molecular weight: 14,984 Da
Basal Isoelectric point: 4.03  Predict pI for various phosphorylation states
CST Pathways:  Translation: eIF4E and p70S6K
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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