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Exportin-5 mediates the nuclear export of proteins bearing double-stranded RNA binding domains and double-stranded RNA. Overexpression enhances RNA interference mediated by shRNAs and miRNAs. In the nucleus it binds cooperatively to its cargo and to Ran in its active GTP-bound form. Docking of this complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause disassembly of the complex and release of the cargo from the export receptor. Exp5 then returns to the nuclear compartment by diffusion through the nuclear pore complex, to mediate another round of transport. Two isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Karyopherin; Nuclear export; Nuclear import; RNA-binding
Chromosomal Location of Human Ortholog: 6p21.1
Cellular Component: cytoplasm; cytosol; nucleoplasm; nucleus
Molecular Function: mRNA binding; nuclear export signal receptor activity; protein binding; Ran GTPase binding; RNA binding
Biological Process: pre-microRNA export from nucleus; protein export from nucleus; regulation of protein export from nucleus
Reference #:  Q9HAV4 (UniProtKB)
Alt. Names/Synonyms: Exp5; exportin 5; Exportin-5; FLJ14239; FLJ32057; FLJ45606; KIAA1291; Ran-binding protein 21; RANBP21; XPO5
Gene Symbols: XPO5
Molecular weight: 136,311 Da
Basal Isoelectric point: 5.56  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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