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Diaphanous-2 Could be involved in oogenesis. Involved in the regulation of endosome dynamics. Implicated in a novel signal transduction pathway, in which isoform 3 and CSK are sequentially activated by RHOD to regulate the motility of early endosomes through interactions with the actin cytoskeleton. Isoform 3 interacts with RHOD in the GTP-bound form. Expressed in testis, ovary, small intestine, prostate, lung, liver, kidney and leukocytes. Belongs to the formin homology family. Diaphanous subfamily. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Cytoskeletal; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: Xq21.33
Cellular Component: cytosol; endoplasmic reticulum; intracellular membrane-bound organelle; nucleolus
Molecular Function: receptor binding
Biological Process: cytokinesis; female gamete generation
Disease: Premature Ovarian Failure 2a
Reference #:  O60879 (UniProtKB)
Alt. Names/Synonyms: DIA; DIA2; DIAP2; DIAPH2; diaphanous 2; diaphanous homolog 2 (Drosophila); Diaphanous-related formin-2; DRF2; FLJ11167; mDia3; POF; POF2; Protein diaphanous homolog 2
Gene Symbols: DIAPH2
Molecular weight: 125,569 Da
Basal Isoelectric point: 6.2  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  Adherens Junction Dynamics  |  Microtubule Dynamics  |  TGF-ß Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

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