Transcription factor that activates the expression of the EIF2S1 (EIF2-alpha) gene. Links the transcriptional modulation of key metabolic genes to cellular growth and development. Implicated in the control of nuclear genes required for respiration, heme biosynthesis, and mitochondrial DNA transcription and replication. Belongs to the NRF1/Ewg family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Molecular Function: protein binding; protein homodimerization activity
Biological Process: generation of precursor metabolites and energy; mitochondrion organization and biogenesis; positive regulation of transcription from RNA polymerase II promoter; regulation of transcription from RNA polymerase II promoter