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PKCT an AGC kinase of the PKC family. A novel PKC: Ca2+ independent but still regulated by PS, DAG and phorbol esters. Contains 2 zinc-dependent phorbol-ester and DAG binding domains. Expressed in skeletal muscle and hematopoietic cells. May play a role in T cell receptor signaling and insulin resistance. Required for TCR-induced NF-kappaB activation in mature T lymphocytes. Note: This description may include information from UniProtKB.
Protein type: AGC group; Delta subfamily; EC; Kinase, protein; PKC family; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor)
Chromosomal Location of Human Ortholog: 10p15.1
Cellular Component: cytosol; intracellular; microtubule organizing center; plasma membrane
Molecular Function: protein binding; protein kinase activity; protein serine/threonine kinase activity
Biological Process: activation of NF-kappaB transcription factor; axon guidance; membrane protein ectodomain proteolysis; negative regulation of insulin receptor signaling pathway; peptidyl-serine phosphorylation; platelet activation; positive regulation of interleukin-17 production; positive regulation of interleukin-4 production; positive regulation of T cell activation; positive regulation of telomerase activity; positive regulation of telomere maintenance via telomerase; regulation of transcription, DNA-dependent; T cell receptor signaling pathway
Reference #:  Q04759 (UniProtKB)
Alt. Names/Synonyms: KPCT; MGC126514; MGC141919; nPKC-theta; PKC-theta; PKCQ; PKCtheta; PRKCQ; PRKCT; Protein kinase C theta type; protein kinase C, theta
Gene Symbols: PRKCQ
Molecular weight: 81,865 Da
Basal Isoelectric point: 7.69  Predict pI for various phosphorylation states
CST Pathways:  Apoptosis Regulation  |  B Cell Receptor Signaling  |  ErbB/HER Signaling  |  GPCR Signaling to MAPKs  |  Growth And Differentiation Control by MAPKs  |  Inhibition of Apoptosis  |  Insulin Receptor Signaling  |  Mitochondrial Control of Apoptosis  |  Phospholipase Signaling  |  Protein Kinase C Signaling  |  T Cell Receptor Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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