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PKCE an AGC kinase of the PKC family. Calcium-independent, phospholipid-dependent. Activated by inflammatory mediators and involved in nociceptive functions. PKC-epsilon null mice display decreased hypoxic pulmonary vasoconstriction. Note: This description may include information from UniProtKB.
Protein type: AGC group; EC; Eta subfamily; Kinase, protein; PKC family; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor)
Chromosomal Location of Human Ortholog: 2p21
Cellular Component: cytoplasm; cytosol; endoplasmic reticulum; Golgi apparatus; perinuclear region of cytoplasm; plasma membrane
Molecular Function: actin monomer binding; enzyme activator activity; enzyme binding; protein binding; protein kinase C activity; protein serine/threonine kinase activity; signal transducer activity
Biological Process: apoptosis; lipopolysaccharide-mediated signaling pathway; peptidyl-serine phosphorylation; phospholipase C activation; platelet activation; positive regulation of actin filament polymerization; positive regulation of cytokinesis; protein amino acid phosphorylation; signal transduction
Reference #:  Q02156 (UniProtKB)
Alt. Names/Synonyms: KPCE; MGC125656; MGC125657; nPKC-epsilon; PKCE; PRKCE; Protein kinase C epsilon type; protein kinase C, epsilon
Gene Symbols: PRKCE
Molecular weight: 83,674 Da
Basal Isoelectric point: 6.73  Predict pI for various phosphorylation states
CST Pathways:  Apoptosis Regulation  |  B Cell Receptor Signaling  |  ErbB/HER Signaling  |  GPCR Signaling to MAPKs  |  Growth And Differentiation Control by MAPKs  |  Inhibition of Apoptosis  |  Mitochondrial Control of Apoptosis  |  Phospholipase Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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