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TNF-R2 Receptor with high affinity for TNFSF2/TNF-alpha and approximately 5-fold lower affinity for homotrimeric TNFSF1/lymphotoxin-alpha. The TRAF1/TRAF2 complex recruits the apoptotic suppressors BIRC2 and BIRC3 to TNFRSF1B/TNFR2. This receptor mediates most of the metabolic effects of TNF-alpha. Isoform 2 blocks TNF-alpha-induced apoptosis, which suggests that it regulates TNF-alpha function by antagonizing its biological activity. Binds to TRAF2. Interacts with BMX. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Receptor, cytokine
Chromosomal Location of Human Ortholog: 1p36.22
Cellular Component: cell soma; extracellular region; integral component of plasma membrane; membrane raft; nucleus; perinuclear region of cytoplasm; plasma membrane
Molecular Function: protein binding; tumor necrosis factor-activated receptor activity; ubiquitin protein ligase binding
Biological Process: aging; DNA damage response, signal transduction resulting in induction of apoptosis; immune response; inflammatory response; multicellular organism development; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; negative regulation of inflammatory response; neutrophil degranulation; positive regulation of membrane protein ectodomain proteolysis; regulation of cell proliferation; RNA destabilization; tumor necrosis factor-mediated signaling pathway
Reference #:  P20333 (UniProtKB)
Alt. Names/Synonyms: CD120b; p75; p75 TNF receptor; p75TNFR; p80 TNF-alpha receptor; soluble TNFR1B variant 1; TBP-2; TBPII; TNF-R-II; TNF-R2; TNF-R75; TNF-RII; TNFBR; TNFR-II; TNFR1B; TNFR2; TNFR80; TNFRSF1B; TNR1B; tumor necrosis factor beta receptor; tumor necrosis factor binding protein 2; Tumor necrosis factor receptor 2; Tumor necrosis factor receptor superfamily member 1B; Tumor necrosis factor receptor superfamily member 1b, membrane form; tumor necrosis factor receptor superfamily, member 1B; Tumor necrosis factor receptor type II; Tumor necrosis factor-binding protein 2
Gene Symbols: TNFRSF1B
Molecular weight: 48,291 Da
Basal Isoelectric point: 5.88  Predict pI for various phosphorylation states
CST Pathways:  Death Receptor Signaling  |  NF-kB Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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