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NELFCD Essential component of the NELF complex, a complex that negatively regulates the elongation of transcription by RNA polymerase II. The NELF complex, which acts via an association with the DSIF complex and causes transcriptional pausing, is counteracted by the P-TEFb kinase complex. The NELF complex is composed of 4 subunits: WHSC2/NELF-A, COBRA1/NELF-B, TH1L (isoform NELF-C or isoform NELF-D) and RDBP/NELF-E. Interacts with ARAF1. Widely expressed. Expressed in heart, brain, lung, placenta, liver, skeletal and cardiac muscle, adrenal, thyroid, kidney and pancreas. Belongs to the NELF-D family. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold
Chromosomal Location of Human Ortholog: 20q13.32
Cellular Component: membrane; nucleoplasm
Molecular Function: protein binding
Biological Process: positive regulation of viral transcription; RNA elongation from RNA polymerase II promoter; transcription from RNA polymerase II promoter
Reference #:  Q8IXH7 (UniProtKB)
Alt. Names/Synonyms: HSPC130; Negative elongation factor C/D; negative elongation factor proteins C and D; NELF-C; NELF-C/D; NELF-D; NELFCD; NELFD; TH1; TH1 drosophila homolog; TH1-like (Drosophila); TH1-like protein; TH1L; trihydrophobin 1
Gene Symbols: NELFCD
Molecular weight: 66,247 Da
Basal Isoelectric point: 4.98  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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