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Protein Page:

PANK4 a pantothenate kinase that catalyzes the first committed step in the biosynthesis of coenzyme A, an essential cofactor in cellular metabolism. PANK4 is ubiquitously expressed but is enriched in muscle. Plays a role in the physiological regulation of the intracellular CoA concentration. Regulated by feedback inhibition by CoA and its thioesters. Interacts with M2-type pyruvate kinase (PKM2) and may modulate glucose metabolism through regulating the activity of PKM2. Expression is up-regulated by high glucose concentrations. Note: This description may include information from UniProtKB.
Protein type: Cofactor and Vitamin Metabolism - pantothenate and CoA biosynthesis; EC; Kinase, other
Chromosomal Location of Human Ortholog: 1p36.32
Reference #:  Q9NVE7 (UniProtKB)
Alt. Names/Synonyms: DKFZp547M242; FLJ10782; hPanK4; PANK4; Pantothenate kinase 4; Pantothenic acid kinase 4
Gene Symbols: PANK4
Molecular weight: 85,991 Da
Basal Isoelectric point: 5.88  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

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