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MYPT1 myosin phosphatase target subunit 1, a regulatory subunit of protein phosphatase 1. Also called the myosin-binding subunit of myosin phosphatase. Myosin phosphatase regulates the interaction of actin and myosin downstream of the guanosine triphosphatase Rho. Four splice-variant isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis; Protein phosphatase, regulatory subunit
Chromosomal Location of Human Ortholog: 12q21.2-q21.31
Cellular Component: A band; actin cytoskeleton; centrosome; contractile fiber; cytosol; focal adhesion; kinetochore; nucleoplasm; Z disc
Molecular Function: enzyme inhibitor activity; phosphatase regulator activity; protein binding; protein kinase binding
Biological Process: centrosome cycle; G2/M transition of mitotic cell cycle; mitotic cell cycle; negative regulation of catalytic activity; positive regulation of transcription from RNA polymerase II promoter; protein amino acid dephosphorylation; regulation of cell adhesion
Reference #:  O14974 (UniProtKB)
Alt. Names/Synonyms: MBS; MGC133042; Myosin phosphatase target subunit 1; myosin phosphatase, target subunit 1; Myosin phosphatase-targeting subunit 1; MYPT1; PPP1R12A; Protein phosphatase 1 regulatory subunit 12A; protein phosphatase 1, regulatory (inhibitor) subunit 12A; Protein phosphatase myosin-binding subunit
Gene Symbols: PPP1R12A
Molecular weight: 115,281 Da
Basal Isoelectric point: 5.31  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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