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LPIN1 Plays important roles in controlling the metabolism of fatty acids at differents levels. Acts as a magnesium-dependent phosphatidate phosphatase enzyme which catalyzes the conversion of phosphatidic acid to diacylglycerol during triglyceride, phosphatidylcholine and phosphatidylethanolamine biosynthesis in the reticulum endoplasmic membrane. Acts also as a nuclear transcriptional coactivator for PPARGC1A/PPARA to modulate lipid metabolism gene expression. Is involved in adipocyte differentiation. May also be involved in mitochondrial fission by converting phosphatidic acid to diacylglycerol. Interacts (via LXXIL motif) with PPARA. Interacts with PPARGC1A. Interaction with PPARA and PPARGC1A leads to the formation of a complex that modulates gene transcription. Interacts with MEF2C. Specifically expressed in skeletal muscle. Also abundant in adipose tissue. Lower levels in some portions of the digestive tract. Inhibited by N-ethylmaleimide. Belongs to the lipin family. Note: This description may include information from UniProtKB.
Protein type: EC; Phosphatase, lipid
Chromosomal Location of Human Ortholog: 2p25.1
Cellular Component: cytoplasm; endoplasmic reticulum membrane; mitochondrial outer membrane; nuclear envelope; nuclear membrane; nucleoplasm; nucleus
Molecular Function: phosphatidate phosphatase activity; transcription coactivator activity
Biological Process: fatty acid catabolic process; mitotic nuclear envelope disassembly; phosphatidylcholine biosynthetic process; phosphatidylethanolamine biosynthetic process; positive regulation of transcription from RNA polymerase II promoter; triacylglycerol biosynthetic process; triacylglycerol mobilization
Disease: Myoglobinuria, Acute Recurrent, Autosomal Recessive
Reference #:  Q14693 (UniProtKB)
Alt. Names/Synonyms: DKFZp781P1796; KIAA0188; lipin 1; Lipin-1; LPIN1; PAP1; Phosphatidate phosphatase LPIN1
Gene Symbols: LPIN1
Molecular weight: 98,664 Da
Basal Isoelectric point: 6.14  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

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