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MKK7 a dual-specificity protein kinase of the STE7 family. Activates JNK1 and -2 by phosphorylating a Thr and a Tyr residue in the activation loop. Is activated by proinflammatory cytokines and environmental stress. Three alternatively spliced isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC; Kinase, protein; Protein kinase, STE; Protein kinase, dual-specificity (non-receptor); STE group; STE7 family
Chromosomal Location of Human Ortholog: 8|8 A1.1
Cellular Component: cytoplasm; cytosol; nucleus
Molecular Function: ATP binding; enzyme binding; JUN kinase kinase activity; magnesium ion binding; MAP kinase kinase activity; mitogen-activated protein kinase kinase kinase binding; protein binding; protein C-terminus binding; protein kinase binding; protein phosphatase binding; protein serine/threonine kinase activity
Biological Process: activation of JNK activity; JNK cascade; positive regulation of neuron apoptosis; positive regulation of protein amino acid phosphorylation; positive regulation of telomerase activity; positive regulation of telomere maintenance via telomerase; protein amino acid phosphorylation; regulation of mitotic cell cycle; response to heat; response to osmotic stress; response to stress; response to UV; response to wounding; stress-activated MAPK cascade
Reference #:  Q8CE90 (UniProtKB)
Alt. Names/Synonyms: 5930412N11Rik; c-Jun N-terminal kinase kinase 2; Dual specificity mitogen-activated protein kinase kinase 7; JNK kinase 2; JNK-activating kinase 2; JNKK 2; Jnkk2; MAP kinase kinase 7; Map2k7; MAPK/ERK kinase 7; MAPKK 7; MEK 7; mitogen activated protein kinase kinase 7; mitogen-activated protein kinase kinase 7; Mkk7; MP2K7; OTTMUSP00000017733; OTTMUSP00000017734; Prkmk7; protein kinase, mitogen activated, kinase 7; sek2
Gene Symbols: Map2k7
Molecular weight: 59,312 Da
Basal Isoelectric point: 9.28  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  B Cell Receptor Signaling  |  Death Receptor Signaling  |  ErbB/HER Signaling  |  GPCR Signaling to MAPKs  |  IL6 Signaling  |  Parkinson's Disease  |  SAPK/JNK Signaling Cascades  |  T Cell Receptor Signaling  |  Toll-Like Receptor Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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