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NCBP1 mediates U snRNA export from the nucleus. Binds to 5' capped mRNA. Found in aU snRNA export complex with RNUXA/PHAX, CBP20, CBP80, RAN, XPO1 and m7G-capped RNA. Interaction with RNUXA/PHAX. Heterodimer with NCBP2. Is part of the exon junction complex (EJC) containing NCBP1, NCBP2, RNPS1, RBM8A, SRRM1, NXF1, UPF3B, UPF2, THOC4 and/or REFBP2. Note: This description may include information from UniProtKB.
Protein type: RNA processing; Spliceosome; Translation
Chromosomal Location of Human Ortholog: 9q22.33
Cellular Component: cytosol; mitochondrion; mRNA cap complex; nucleoplasm; nucleus; ribonucleoprotein complex
Molecular Function: mRNA binding; protein binding; RNA 7-methylguanosine cap binding; RNA binding; RNA cap binding
Biological Process: fibroblast growth factor receptor signaling pathway; histone mRNA metabolic process; mRNA 3'-end processing; mRNA capping; mRNA catabolic process, nonsense-mediated decay; mRNA export from nucleus; nuclear export; nuclear mRNA splicing, via spliceosome; positive regulation of cell growth; positive regulation of mRNA 3'-end processing; positive regulation of nuclear mRNA splicing, via spliceosome; primary microRNA processing; regulation of translational initiation; RNA elongation from RNA polymerase II promoter; RNA export from nucleus; RNA metabolic process; RNA splicing; snRNA transcription from RNA polymerase II promoter; spliceosome assembly; termination of RNA polymerase II transcription; transcription from RNA polymerase II promoter
Reference #:  Q09161 (UniProtKB)
Alt. Names/Synonyms: 80 kDa nuclear cap-binding protein; CBP80; MGC2087; NCBP; NCBP 80 kDa subunit; NCBP1; nuclear cap binding protein subunit 1, 80kDa; Nuclear cap-binding protein subunit 1; Sto1
Gene Symbols: NCBP1
Molecular weight: 91,839 Da
Basal Isoelectric point: 5.99  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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