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Protein Page:

MIB2 E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. Positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors. 9 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: EC 6.3.2.-; Ligase; Ubiquitin conjugating system; Ubiquitin ligase
Chromosomal Location of Human Ortholog: 1p36.33
Cellular Component: cytoplasm; cytosol
Molecular Function: protein binding; signal transducer activity; ubiquitin-protein ligase activity
Biological Process: positive regulation of I-kappaB kinase/NF-kappaB cascade; protein polyubiquitination
Reference #:  Q96AX9 (UniProtKB)
Alt. Names/Synonyms: E3 ubiquitin-protein ligase MIB2; FLJ20648; FLJ39787; FLJ41406; MIB2; Mind bomb homolog 2; mindbomb homolog 2 (Drosophila); Novelzin; Putative NF-kappa-B-activating protein 002N; SKD; Skeletrophin; Zinc finger ZZ type with ankyrin repeat domain protein 1; zinc finger, ZZ type with ankyrin repeat domain 1; ZZANK1; ZZZ5
Gene Symbols: MIB2
Molecular weight: 109,939 Da
Basal Isoelectric point: 8.81  Predict pI for various phosphorylation states
CST Pathways:  Notch Signaling
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Protein Structure Not Found.

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