Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
Home | Login
About PhosphoSiteUsing PhosphoSiteprivacy & cookiesCuration ProcessContact
logos LINCs Logo Mt Sinai Logo NIH Logo NCI Logo
Search / Browse Functions
Protein Page:

ITGB1 an integral membrane protein that heterodimerizes with an alpha-3 chain, forming a receptor for many extracellular-matrix proteins including fibronectin, laminin, collagen, epiligrin and thrombospondin. . Beta 1 integrins recognize the amino-acid motif RGD in a wide array of ligands. Five alternatively spliced variants with alternate carboxy termini have been described. Two alternatively spliced isoforms have been described. Isoform beta-1a is widely expressed; other isoforms are generally expressed with a more restricted distribution. Isoform beta-1b is expressed in skin, liver, skeletal muscle, cardiac muscle, placenta, umbilical vein endothelial cells, neuroblastoma cells, lymphoma cells, hepatoma cells and astrocytoma cells. Isoforms beta-1c and beta-1c-2 are expressed in muscle, kidney, liver, placenta, cervical epithelium, umbilical vein endothelial cells, fibroblast cells, embryonal kidney cells, platelets and several blood cell lines. Isoform beta-c-2, rather than isoform beta-1c, is selectively expressed in primary t-cells. Isoform beta-1c is expressed in nonproliferating and differentiated prostate gland epithelial cells. Isoform beta-1d is expressed specifically in striated muscle (skeletal and cardiac muscle). Note: This description may include information from UniProtKB.
Protein type: Cell adhesion; Cell surface; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc.
Chromosomal Location of Human Ortholog: 10p11.22
Cellular Component: cell surface; cleavage furrow; cytoplasm; dendritic spine; external side of plasma membrane; extracellular exosome; filopodium; focal adhesion; integrin alpha1-beta1 complex; integrin alpha10-beta1 complex; integrin alpha11-beta1 complex; integrin alpha2-beta1 complex; integrin alpha3-beta1 complex; integrin alpha7-beta1 complex; integrin alpha8-beta1 complex; integrin complex; intercalated disc; invadopodium membrane; lamellipodium; melanosome; membrane; membrane raft; neuromuscular junction; perinuclear region of cytoplasm; plasma membrane; receptor complex; recycling endosome; ruffle; sarcolemma
Molecular Function: actin binding; C-X3-C chemokine binding; cadherin binding; cell adhesion molecule binding; collagen binding involved in cell-matrix adhesion; coreceptor activity; fibronectin binding; integrin binding; laminin binding; metal ion binding; protease binding; protein binding; protein complex binding; protein heterodimerization activity; viral receptor activity
Biological Process: axon extension; B cell differentiation; basement membrane organization; calcium-independent cell-matrix adhesion; cardiac muscle cell differentiation; cell adhesion mediated by integrin; cell fate specification; cell migration; cell migration during sprouting angiogenesis; cell-cell adhesion mediated by integrin; cell-matrix adhesion; cell-substrate adhesion; cellular defense response; cellular response to low-density lipoprotein particle stimulus; dendrite morphogenesis; entry of virus into host cell; extracellular matrix organization; formation of radial glial scaffolds; G1/S transition of mitotic cell cycle; germ cell migration; heterotypic cell-cell adhesion; homophilic cell adhesion; in utero embryonic development; integrin-mediated signaling pathway; leukocyte adhesion; leukocyte migration; leukocyte tethering or rolling; mesodermal cell differentiation; negative regulation of anoikis; negative regulation of cell differentiation; negative regulation of Rho protein signal transduction; positive regulation of apoptosis; positive regulation of cell proliferation; positive regulation of GTPase activity; receptor internalization; regulation of cell cycle; regulation of collagen catabolic process; regulation of immune response; sarcomere organization; stress fiber assembly; transforming growth factor beta receptor signaling pathway; visual learning
Reference #:  P05556 (UniProtKB)
Alt. Names/Synonyms: CD29; fibronectin receptor beta subunit; Fibronectin receptor subunit beta; FNRB; GPIIA; Integrin beta-1; integrin VLA-4 beta subunit; integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12); ITB1; ITGB1; MDF2; MSK12; VLA-4 subunit beta; VLA-BETA; VLAB
Gene Symbols: ITGB1
Molecular weight: 88,415 Da
Basal Isoelectric point: 5.27  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  GPCR Signaling to MAPKs  |  Growth And Differentiation Control by MAPKs  |  PI3K/Akt Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below


Protein Structure Not Found.
Download PyMol Script
Download ChimeraX Script

STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Scansite  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein