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FREQ Neuronal calcium sensor, regulator of G protein-coupled receptor phosphorylation in a calcium dependent manner. Directly regulates GRK1 (RHOK), but not GRK2 to GRK5. Can substitute for calmodulin. Stimulates PI4KB kinase activity. Involved in long-term synaptic plasticity through its interaction with PICK1. May also play a role in neuron differentiation through inhibition of the activity of N- type voltage-gated calcium channel. Interacts with KCND2. Interacts in a calcium-independent manner with PI4KB. This binding competes with CALN2/CABP7 binding to PI4KB. Interacts with ARF1, ARF3, ARF5 and ARF6. Interacts in a calcium-dependent manner with PICK1 (via AH domain). Interacts with IL1RAPL1. Belongs to the recoverin family. Note: This description may include information from UniProtKB.
Protein type: Calcium-binding
Chromosomal Location of Human Ortholog: 9q34.11
Cellular Component: cytoplasm; intracellular membrane-bound organelle; plasma membrane
Molecular Function: calcium ion binding; protein binding; voltage-gated calcium channel activity
Reference #:  P62166 (UniProtKB)
Alt. Names/Synonyms: DKFZp761L1223; FLUP; FREQ; Frequenin homolog; Frequenin-like protein; Frequenin-like ubiquitous protein; NCS-1; NCS1; Neuronal calcium sensor 1
Gene Symbols: NCS1
Molecular weight: 21,879 Da
Basal Isoelectric point: 4.71  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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