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BSG Plays pivotal roles in spermatogenesis, embryo implantation, neural network formation and tumor progression. Stimulates adjacent fibroblasts to produce matrix metalloproteinases (MMPS). May target monocarboxylate transporters SLC16A1, SLC16A3 and SLC16A8 to plasma membranes of retinal pigment epithelium and neural retina. Seems to be a receptor for oligomannosidic glycans. In vitro, promotes outgrowth of astrocytic processes. Enriched on the surface of tumor cells. Up-regulated in gliomas. Its expression levels correlate with malignant potential of the tumor. Forms homooligomers in a cis-dependent manner on the plasma membrane. Forms a complex with MMP1 at the tumor cell surface. Interacts with SLC16A1 and SLC1A3; probably a BSG dimer is associated with a monocarboxylate transporter dimer. Interacts with ATP1B2, MAG and L1CAM. Interacts with AJAP1. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Immunoglobulin superfamily; Membrane protein, integral
Chromosomal Location of Human Ortholog: 19p13.3
Cellular Component: acrosomal membrane; focal adhesion; Golgi membrane; integral component of plasma membrane; intracellular membrane-bound organelle; melanosome; membrane; membrane raft; mitochondrion; plasma membrane; sarcolemma
Molecular Function: cadherin binding; mannose binding; monocarboxylic acid transmembrane transporter activity; protein binding
Biological Process: cell surface receptor signaling pathway; decidualization; embryo implantation; extracellular matrix disassembly; extracellular matrix organization; leukocyte migration; monocarboxylic acid transport; odontogenesis of dentine-containing teeth; pyruvate metabolic process; response to cAMP; response to mercury ion; response to peptide hormone
Disease: Blood Group--ok
Reference #:  P35613 (UniProtKB)
Alt. Names/Synonyms: 5F7; BASI; Basigin; basigin (Ok blood group); BSG; CD147; CD147 antigen; Collagenase stimulatory factor; EMMPRIN; Extracellular matrix metalloproteinase inducer; Leukocyte activation antigen M6; M6; OK; OK blood group antigen; TCSF; Tumor cell-derived collagenase stimulatory factor
Gene Symbols: BSG
Molecular weight: 42,200 Da
Basal Isoelectric point: 5.39  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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