Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
Home | Login
About PhosphoSiteUsing PhosphoSiteprivacy & cookiesCuration ProcessContact
logos LINCs Logo Mt Sinai Logo NIH Logo NCI Logo
Search / Browse Functions
Protein Page:

TIM-3 Regulates macrophage activation. Inhibits T-helper type 1 lymphocyte (Th1)-mediated auto- and alloimmune responses and promotes immunological tolerance. May be also involved in T-cell homing. Receptor for LGALS9. Belongs to the immunoglobulin superfamily. TIM family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Receptor, misc.
Chromosomal Location of Human Ortholog: 5q33.3
Cellular Component: cell junction; cell surface; early endosome; immunological synapse; integral component of membrane
Molecular Function: metal ion binding; protein binding
Biological Process: adaptive immune response; defense response to Gram-positive bacterium; inflammatory response; innate immune response; macrophage activation involved in immune response; maternal process involved in female pregnancy; natural killer cell tolerance induction; negative regulation of interferon-alpha production; negative regulation of interferon-gamma production; negative regulation of interleukin-2 production; negative regulation of interleukin-3 production; negative regulation of interleukin-6 production; negative regulation of myeloid dendritic cell activation; negative regulation of natural killer cell activation; negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target; negative regulation of NF-kappaB transcription factor activity; negative regulation of T cell proliferation; negative regulation of T-helper 1 type immune response; negative regulation of tumor necrosis factor production; positive regulation of chemokine production; positive regulation of interferon-gamma production; positive regulation of interleukin-1 production; positive regulation of interleukin-4 production; positive regulation of macrophage activation; positive regulation of T cell proliferation; regulation of tolerance induction dependent upon immune response; toll-like receptor 3 signaling pathway; toll-like receptor 7 signaling pathway; toll-like receptor 9 signaling pathway
Disease: Rheumatoid Arthritis
Reference #:  Q8TDQ0 (UniProtKB)
Alt. Names/Synonyms: FLJ14428; HAVcr-2; HAVCR2; Hepatitis A virus cellular receptor 2; kidney injury molecule-3; KIM-3; T cell immunoglobulin mucin 3; T cell immunoglobulin mucin-3; T-cell immunoglobulin and mucin domain-containing protein 3; T-cell membrane protein 3; TIM-3; TIM3; TIMD-3; TIMD3
Gene Symbols: HAVCR2
Molecular weight: 33,394 Da
Basal Isoelectric point: 5.54  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below


Protein Structure Not Found.
Download PyMol Script
Download ChimeraX Script

STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Scansite  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein