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DDIT4 Inhibits cell growth by regulating the TOR signaling pathway upstream of the TSC1-TSC2 complex and downstream of AKT1. Promotes neuronal cell death. Up-regulated in fibroblasts upon ionizing radiation, via a TP53-dependent pathway. Up-regulated by TP63 in primary keratinocytes, and down-regulated during keratinocyte differentiation. Up-regulated upon DNA alkylation. Up-regulated by amyloid beta-peptide and retinoic acid. Up-regulated by hypoxia, via a PI3K and HIF1A-dependent but TP53/TP63-independent mechanism. Broadly expressed, with lowest levels in brain, skeletal muscle and intestine. Up-regulated in substantia nigra neurons from Parkinson disease patients. Belongs to the DDIT4 family. Note: This description may include information from UniProtKB.
Chromosomal Location of Human Ortholog: 10q22.1
Cellular Component: cytoplasm; cytosol; intracellular
Biological Process: brain development; cell proliferation; defense response to virus; DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis; negative regulation of peptidyl-serine phosphorylation; negative regulation of TOR signaling pathway; nerve growth factor receptor signaling pathway; neuron differentiation; neuron migration; response to hypoxia
Reference #:  Q9NX09 (UniProtKB)
Alt. Names/Synonyms: DDIT4; Dig2; DNA damage-inducible transcript 4 protein; DNA-damage-inducible transcript 4; FLJ20500; HIF-1 responsive protein RTP801; HIF-1 responsive RTP801 (RTP801); Protein regulated in development and DNA damage response 1; REDD-1; REDD1; RP11-442H21.1; RTP801
Gene Symbols: DDIT4
Molecular weight: 25,371 Da
Basal Isoelectric point: 4.87  Predict pI for various phosphorylation states
CST Pathways:  mTOR Signaling  |  Parkinson's Disease
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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