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JAG1 Ligand for multiple Notch receptors and involved in the mediation of Notch signaling. May be involved in cell-fate decisions during hematopoiesis. Seems to be involved in early and late stages of mammalian cardiovascular development. Inhibits myoblast differentiation. Enhances fibroblast growth factor-induced angiogenesis (in vitro). Interacts with NOTCH2 and NOTCH3. Interacts with NOTCH1 (in the presence of calcium ions). Widely expressed in adult and fetal tissues. In cervix epithelium expressed in undifferentiated subcolumnar reserve cells and squamous metaplasia. Expression is up-regulated in cervical squamous cell carcinoma. Expressed in bone marrow cell line HS-27a which supports the long-term maintenance of immature progenitor cells. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral
Chromosomal Location of Human Ortholog: 20p12.2
Cellular Component: adherens junction; apical plasma membrane; extracellular region; integral component of plasma membrane; membrane; plasma membrane
Molecular Function: calcium ion binding; growth factor activity; Notch binding; phospholipid binding; protein binding; structural molecule activity
Biological Process: angiogenesis; auditory receptor cell differentiation; blood vessel remodeling; cell fate determination; endothelial cell differentiation; hemopoiesis; keratinocyte differentiation; morphogenesis of an epithelial sheet; myoblast differentiation; negative regulation of endothelial cell differentiation; negative regulation of fat cell differentiation; negative regulation of neuron differentiation; nervous system development; Notch receptor processing; Notch signaling pathway; positive regulation of myeloid cell differentiation; positive regulation of Notch signaling pathway; positive regulation of osteoblast differentiation; positive regulation of transcription from RNA polymerase II promoter; regulation of cell migration; regulation of cell proliferation; response to muramyl dipeptide; T cell mediated immunity
Disease: Alagille Syndrome 1; Tetralogy Of Fallot
Reference #:  P78504 (UniProtKB)
Alt. Names/Synonyms: AGS; AHD; AWS; CD339; hJ1; JAG1; jagged 1 (Alagille syndrome); Jagged1; JAGL1; MGC104644; Protein jagged-1
Gene Symbols: JAG1
Molecular weight: 133,799 Da
Basal Isoelectric point: 5.7  Predict pI for various phosphorylation states
CST Pathways:  Notch Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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