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RAB35 In the process of endocytosis, essential rate-limiting regulator of a fast recycling pathway back to the plasma membrane. During cytokinesis, required for the postfurrowing terminal steps, namely for intercellular bridge stability and abscission, possibly by controlling phosphatidylinositol 4,5-bis phosphate (PIP2) and SEPT2 localization at the intercellular bridge. Interacts with DENND1A and DENND1B in a nucleotide- dependent manner. The low binding to DENND1C is nucleotide- independent. All 3 DENND1 act as GEFs for RAB35 and thus activate the protein. Belongs to the small GTPase superfamily. Rab family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: G protein; G protein, monomeric; G protein, monomeric, Rab
Chromosomal Location of Human Ortholog: 12q24.23
Cellular Component: cell projection membrane; clathrin coated vesicle membrane; clathrin-coated endocytic vesicle; coated pit; cytosol; endosome membrane; intercellular bridge; plasma membrane; recycling endosome membrane
Molecular Function: GDP binding; GTP binding; GTPase activity; phosphatidylinositol-4,5-bisphosphate binding; protein binding
Biological Process: antigen processing and presentation; cytokinesis; endocytic recycling; endosome transport; neurite development; plasma membrane to endosome transport; protein localization
Reference #:  Q15286 (UniProtKB)
Alt. Names/Synonyms: GTP-binding protein RAY; H-ray; RAB1C; RAB35; RAB35, member RAS oncogene family; Ras-related protein Rab-1C; ras-related protein rab-1c (GTP-binding protein ray); Ras-related protein Rab-35; RAY
Gene Symbols: RAB35
Molecular weight: 23,025 Da
Basal Isoelectric point: 8.53  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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